Medindia

Ancient Chinese Herb Triggers Hair Regrowth Pathway

Study shows a traditional Chinese root extract activates Wnt beta catenin signalling and boosts hair follicle growth in lab models for hair loss therapy.
Reuters

Avalon Pharma announces beta-catenin pathway inhibitors demonstrate significant tumor growth inhibition

Co announced that compounds from its Beta-catenin pathway inhibitor program demonstrated significant tumor growth inhibition in multiple animal models. The results will be presented today at the ...
ascopubs.org

Impact of Baseline β-Catenin Comutations on Prognosis in EGFR-Mutant Lung Cancer

A retrospective analysis of 1,804 patients with NSCLC undergoing next-generation sequencing (NGS) in 2019-2024 at University Hospital Würzburg (single-center cohort, including 15 patients with ...
BioWorld

Disruptor of β-catenin pathway contributes to colorectal tumor suppression

The hyperactivation of the Wnt/β-catenin signaling pathway plays a central role in the progression and expansion of colorectal cancer (CRC). The suppression of this pathway may contribute to the ...
ascopubs.org

A first-in-human, phase 1/2 trial of FOG-001, a β-catenin:TCF antagonist, in patients with locally advanced or metastatic solid tumors.

First-in-human, phase 1/2 study of GSK4524101, an oral DNApolymerase theta inhibitor (POLQi), alone or combined with the poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) niraparib in adults with ...
EurekAlert!

Advances and challenges in targeted therapy for colorectal cancer: A focus on adenomatous polyposis coli and kirsten rat sarcoma virus mutations

APC, adenomatous polyposis coli; CBP, cAMP-response element binding protein; CIBP, calcium- and integrin-binding protein; CK, creatine kinase. CtBP, C-terminal binding protein; GRO, growth-regulated ...