Though these drugs had little direct effect on cardiac ion channels, the effects that were seen were due to blockade of hERG potassium channels. Thioridazine and sertindole had the highest ...

Heat increases heart rate across vertebrates. Here, authors pinpoint a motif in the HCN4 channel that governs heat-driven heart rate acceleration and demonstrate its conserved role in other HCN ...

Medicine often takes a one-size-fits-all approach, but a disorder's root cause can vary. Vanderbilt researchers have found that for people with long QT syndrome, a heart condition that causes an ...

Researchers have confirmed that mammalian BK ion channels regulate themselves using a “ball-and-chain” mechanism. A recent ...

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function ...

Ion channels are integral membrane protein assemblies ... Na + pumping mechanism of this ancient system. Heat increases heart rate across vertebrates. Here, authors pinpoint a motif in the HCN4 ...

"Our results complement fantastic pioneering work on the personalized medicine of ion channel-based heart disease being carried out by a number of labs in the medical center, including those of ...