Though these drugs had little direct effect on cardiac ion channels, the effects that were seen were due to blockade of hERG potassium channels. Thioridazine and sertindole had the highest ...

Heat increases heart rate across vertebrates. Here, authors pinpoint a motif in the HCN4 channel that governs heat-driven heart rate acceleration and demonstrate its conserved role in other HCN ...

Medicine often takes a one-size-fits-all approach, but a disorder's root cause can vary. Vanderbilt researchers have found that for people with long QT syndrome, a heart condition that causes an ...

Research by our faculty members focuses on a variety of subjects including cardiovascular ion channels, calcium handling proteins, heart development, cardiac diseases such as cardiac arrhythmias, ...

Their work focuses on congenital heart diseases such as dysfunction of cardiac ion channels (channelopathies) and contractile proteins (cardiomyopathies), both of which can result in arrhythmias and ...

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function ...

Ion channels are integral membrane protein assemblies ... Na + pumping mechanism of this ancient system. Heat increases heart rate across vertebrates. Here, authors pinpoint a motif in the HCN4 ...