Cataplexy, or sudden muscle weakness that can resemble fainting, may be prompted by strong emotions. This symptom isn't serious and mostly occurs with narcolepsy type one — otherwise, it's very rare.

Alkermes announced today the initiation of the Brilliance Studies, a phase 3 program that will test the safety and efficacy ...

Pitolisant is now the only treatment option not scheduled as a controlled substance that is indicated for both excessive daytime sleepiness and cataplexy in pediatric and adult patients. The Food and ...

Cataplexy is a sudden episode of muscle weakness that occurs while fully aware and conscious. It can be triggered by emotional events, such as laughing, crying or fear, and is usually transient in ...

Pitolisant (Wakix) in children ages 6 years and up led to clinically meaningful improvements in narcolepsy symptoms in a phase III trial. Among 110 kids with narcolepsy with or without cataplexy, ...

The approval was based on data from two phase 3 trials (HARMONY CTP and HARMONY 1) that evaluated the efficacy and safety of pitolisant for the treatment of cataplexy. The Food and Drug Administration ...

Orexins are neurotransmitters, which are chemicals in your brain that send messages from one neuron (a nerve cell) to another. When you’re awake, those neurons send out orexins. The orexins then bind ...

Narcolepsy is a sleep disorder that causes abnormal sleep and wake cycles. It often shows up as an excessive and irresistible urge to sleep during the day, along with restless or disrupted sleep at ...

And not figuratively, either. Sometimes people have found that certain emotions literally cause their muscles to unhook from their brains. They collapse entirely. This is not some strange disease, or ...

We knew something was wrong with Dylan early on. He went from being a happy baby to sleeping constantly. When he was awake, he was angry, irritable and aggressive. We hoped he was suffering from sleep ...

Billie Hodgson is the rare person who can text “ROFL” and not be accused of hyperbole. The UK teen suffers from a rare condition that causes her to fall to the floor every time she laughs. The 17-year ...