Though Horton’s injury loomed over the game, the Cubs still weren’t good enough in Friday’s 4-1 loss to the Guardians.

Harvey (0-1) allowed three runs on two hits and a walk while retiring just two batters in relief to take the loss Friday against the Guardians.

The Knoxville Smokies lost to Birmingham 6-2, bringing the three-game series to a 1-1 split. The Cubs' Seiya Suzuki made his second rehab appearance.

Boyd allowed six runs on six hits with one walk and seven strikeouts in the team’s 10-4 Opening Day loss to a rebuilding Nationals team. Boyd’s velocity was up, and he generated 20 whiffs, four more than his single-game high in 2025, but he allowed an average exit velocity of 98.6 mph.

Cubs radio host makes ridiculous 'must win' comment after Opening Day loss originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The Chicago Cubs began their season on a poor note, losing to the Washington Nationals on Opening Day on a very windy day in Chicago.

The Angels try to challenge a call at the plate but umpires rule they didn’t ask quickly enough. The Cubs score five runs in the inning and the Angels lose, 6-2, in the final game of their season-opening seven-game trip.

The Chicago Cubs and the Cleveland Guardians play the second game of a 3-game series Saturday in Cleveland, Ohio. First pitch set for 7:15 p.m. ET.

With a black ski mask leaving only his eyes exposed to the frigid conditions at Wrigley Field, Cubs center fielder Pete Crow-Armstrong sprinted in pursuit of a fly ball off the bat of Jeimer Candelario in the sixth inning on Tuesday night.