A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.

By connecting with its tumor-associated overexpression ligands, such as MICA, MICB, and ULBPs, NKG2D, an activating NK cell receptor can modulate the cytotoxic capability of NK cells against ...

A relevant example is the fairly recent evolution of entirely different types of NK cell receptors in mice and humans, who last shared a common ancestor around 65 million years ago; mouse NK cells ...

Following the discovery of inhibitory KIR and the understanding that they play a role in preventing NK cell killing of self MHC I-expressing tumor cells, investigators began to research the ...

One such effector cell in the antiviral response is the Natural Killer (NK) cell, which secretes inflammatory cytokines ... a subset of NK cells bearing the activating Ly49H receptor, which ...

Medigene AG (Medigene, FSE: MDG1, Prime Standard), an oncology platform company focused on the research and development of T cell receptor ...

More encouraging advances have been made with allogeneic NK cell therapy in clinical trials to overcome this limitation. In this article, we present developments in NK cell adoptive immunotherapy ...