UB researchers have uncovered how heat causes a critical receptor protein within cells to unfold and relay pain.

For acute low back pain, there is moderate-certainty evidence that nonsteroidal anti-inflammatory drugs are an effective treatment.

The initial pain-dulling sensation occurs when capsaicin activates heat-sensing transient receptor potential vanilloid 1 (TRPV1) ion channels on sensory neurons. Prolonged stimulation with the ...

It's all about a chemical compound in peppers called capsaicin. Capsaicin binds to pain receptors on our nerves called TRPV1. Normally, it reacts to heat by sending warning signals to the brain.

The initiation of electrical impulses that relayed to the brain the searing pain of scalding water or the ... The discovery of TRPV1 served as the catalyst that led to several ion channels being ...

Researchers have long investigated the ion channels known as TRP (transient receptor ... to other noxious chemical stimuli.” To alleviate pain, previous potential therapies have blocked the TRPV1 ...