The targeting of telomeres offers promise for new cancer therapies, which can be aimed at disrupting the mechanisms that ...

In the 1930s, Muller was surprised to note that telomeres were strangely resistant to mutagenic X-rays. Why are the unique properties of these chromosomal "end caps" so important? Thus, in her ...

The starting point for the project is a reconstituted system for DNA replication that we have recently developed in the Telomere Biology lab. Combining this system with chromatinised DNA templates and ...

Furthermore, telomere shortening due to the inability of the DNA-replication machinery to fully replicate the ends is a critical mechanism of tumor suppression as well as a hallmark of aging.

Our cells prevent this excessive shortening by adding telomeric DNA to the ends ... travels to telomere to facilitate ...

A major goal of the Sfeir is to understand the mechanism(s) underlying telomere length regulation, which is critical for cellular survival. We are particularly interested in uncovering the pathway(s) ...

The long, thread-like DNA molecules that carry our genes are packed into ... This experiment showed that the biochemical machinery involved in telomere replication had to be very broadly conserved, ...

Scientists at Children's Medical Research Institute (CMRI) have solved a big mystery in cancer research—why cells die in ...