Every person’s cancer develops and grows in its own way and is unique in terms of what therapies it’s sensitive to. At Memorial Sloan Kettering and at other research centers around the world, the push ...

As cancer progresses, the tumor begins to consist of more diverse cells with a range of molecular signatures and variable sensitivity to treatment. This is called tumor heterogeneity.

The researchers also wanted to develop a method for observing how individual tumor organoids respond to therapy in real time. Scientists commonly use endpoint assays to assess a drug’s effect on an ...

To potentially mitigate some of the challenges posed by such intratumoral heterogeneity, considerable technical development is advancing our ability to profile tumor-derived cfDNA from plasma at both ...

Uncovering the Biological Basis of Tumor Heterogeneity The selective advantage for the establishment and, more interestingly, the maintenance of heterogeneity in tumors is unclear. Our results ...

Despite advances in cancer treatment, certain forms of the disease remain stubbornly difficult to treat, particularly when they recur or spread. Researchers are now turning their attention to the ...

High levels of heterogeneity in a patient’s tumor are typically associated with poor prognosis in breast cancer. Researchers from Dartmouth Cancer Center have developed a new approach for ...

Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution. Journal: Leukemia. DOI: 10.1038/s41375-023-02093-7. Correspondence.

Impact of Tumor Heterogeneity on Testing Reliability. Although ovarian cancer shows relatively limited spatial and temporal heterogeneity compared to other cancers, ...

Tumor heterogeneity is not one distinct term but rather encompasses several facets that render tumors unique. 2,3 At the highest level, there is variability both within an individual tumor (intratumor ...