General Hospital ’s longest recurring actor and portrayer of matriarch Monica Quartermaine, Leslie Charleson, has died at 79. Since the show’s executive producer Frank Valentini shared the news on Sunday, fans and fellow cast members have shared their reactions to the significant loss.

Leslie Charleson, who played cardiologist Monica Quartermaine on "General Hospital" for five decades, has died, according to the soap opera's producer. She was 79.

Leslie Charleson, best known for her role of Monica Quartermaine on General Hospital, has died. She was 79 years old. The soap opera star’s death was announced in a post on the General Hospital official Instagram account on Sunday.

Colleagues are remembering the soap opera star for her "quick wit" and presence on set. She died after a long illness.

Leslie Charleson, who played popular character Dr. Monica Quartermaine for almost 50 years on “General Hospital,” has died, the program’s executive producer announced on Sunday.

Longtime "General Hospital" star Leslie Charleson has died at 79, the show's executive producer Frank Valentini shared in a statement.

ABC Photo Archives/Disney General Entertainment Content via Getty Images Leslie Charleson, who played Dr. Monica Quartermaine on “General Hospital” for nearly half a century, has died ...

Wally Kurth joined General Hospital in 1991 as Ned Ashton, a member of the Quartermaine family — so Ned enjoyed a close relationship with his aunt, Monica Quartermaine, played by Leslie Charleson, who passed away on January 12,

Leslie Charleson, known for her role as Monica Quartermaine on “General Hospital,” has died. She was 79. Executive producer Frank Valentini announced Charleson’s death Sunday on the show’s Instagram page.

Fans and co-workers alike are still reeling from the death of General Hospital legend Leslie Charleson. She began playing Monica Quartermaine on the show in 1977, quickly becoming a fan favorite.

Jan. 14 (UPI) -- NBC renewed the comedy St. Denis Medical on Tuesday. The show airs Thursdays at 8 p.m. EDT and new episodes stream Fridays on Peacock. Allison Tolman plays a nurse who stresses herself out going above and beyond for patients. David Alan Grier plays a gruff veteran doctor.