A parasite that may already be hiding in your brain has a shocking survival trick: it can infect the very immune cells sent to destroy it. Yet most people never get sick, and new research from UVA ...

A new study identifies an extreme but effective way that brain immune cells can prevent the parasite Toxoplasma gondii from spreading: they kill themselves to eliminate the dangerous microbes they ...

Fas ligand (FasL) is a cytokine that induces apoptosis by binding to its cell surface receptor, Fas (ref. 1). Fas is expressed almost ubiquitously in a variety of cells and tissues, whereas FasL ...

Researchers have resolved a 50-year-old scientific mystery by identifying the molecular mechanism that allows tissues to ...

Clusterin, also known as apolipoprotein J, is a ubiquitously expressed molecule thought to influence a variety of processes including cell death. In the brain, it accumulates in dying neurons ...

Autophagy is indispensable for maintaining hepatocyte integrity, metabolic homeostasis, and survival. While several autophagy ...

Researchers at the University of Virginia School of Medicine have identified a specific enzyme inside immune cells that keeps Toxoplasma gondii, one of the most common brain parasites on the planet, ...

A team of researchers has clarified a biological process first observed more than 50 years ago: how tissues rebuild themselves after severe damage. The findings reveal that enzymes linked to cell ...

Growing up, you probably changed your style based on your social influences. It turns out, such pressures affect the ...

A potential breakthrough in the treatment of type 1 mediated chronic inflammatory skin diseases (ISD) has emerged, as researchers have identified receptor-interacting serine/threonine-protein kinase 1 ...

Autophagy is indispensable for maintaining hepatocyte integrity, metabolic homeostasis, and survival. While several autophagy-related proteins have ...

A genetics‑guided drug, compound 6, targets CARD9 to subtly calm gut inflammation in Crohn’s disease, pointing to safer, longer‑lasting, precision treatments.