A protein’s life is anything but simple. Discover how transcription, translation, folding, modification, and degradation work together to preserve proteome integrity.

The dominant theory in neuroscience has been that the sensory processing circuits in our brain are finalized in early ...

For many people diagnosed with cancer, treatment with immune checkpoint inhibitors (ICIs) has dramatically extended lives. Some of these treatments, such as Keytruda and Opdivo, have become familiar ...

For many people diagnosed with cancer, treatment with immune checkpoint inhibitors (ICIs) has dramatically extended lives. Some of these treatments, such as Keytruda and Opdivo, have become familiar ...

HCB101, a novel Fc-based anti-SIRPα-CD47 fusion protein, has received orphan drug designation (ODD) from the FDA for the ...

Protein-Protein Interactions (PPIs) are critical for biological systems to function properly. Strong interactions maintain structural integrity and function, whereas weaker interactions enable ...

A research team led by Professor Ki-Young Lee at the College of Medicine, Sungkyunkwan University, has uncovered a previously unrecognized tumor-intrinsic role of the immune checkpoint molecule PD-L1, ...

Researchers identify that the brain's sensory checkpoint (TRN) undergoes a molecular "upgrade" in adulthood for high-resolution perception.

Researchers found muscle stem cells temporarily reduce PFKM-driven glucose metabolism after stress, rerouting fuel to antioxidant repair before rebuilding. Targeting this metabolic checkpoint could ...

FILE - Ukrainian children play at an abandoned checkpoint in Kherson, southern Ukraine, Wednesday, Nov. 23, 2022.

A Chinese phase 3 trial of Bristol Myers Squibb’s antibody-drug conjugate has hit its dual primary survival endpoints, ...