Background A 54-year-old man presented with fever, abdominal pain, anemia, elevated C-reactive protein level and decreased renal function. Idiopathic retroperitoneal fibrosis (Ormond's disease) had ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell ...

Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response. They are generated ...

Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and ...

The Lancet's interactive Picture Quiz Gallery hosts a new picture quiz each month. Play the picture quiz to test your medical knowledge and diagnostic skills. Each quiz is a multi-choice challenge ...

(D) CD68 (+): a marker of macrophages and histiocytes. (E) Immunohistochemistry positive for CD4. (F) CD163 (+): a specific histiocyte marker. (G) MRI reveals intracranial metastatic lesions. (H, I) ...