A first-round tender would cost the 49ers an estimated $7,279,000 for the 2025 season according to Over the Cap. The ...

Walter Nolen, Seth Campbell and Deontae Lawson are three prospects the 49ers need to target in the 2025 NFL Draft ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...

Arizona State Sun Devils’ Cam Skattebo could be a dream addition for the San Francisco 49ers as they seek to bolster their ...

GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury. On just the ...

Matt Maiocco hands out 49ers grades after San Francisco’s season-ending loss to the Arizona Cardinals on Sunday.

The 49ers lost another running back Sunday. Isaac Guerendo was carted off the field with injuries to his left knee and ankle. The team ruled out his ...

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The ...

The 49ers have had to rely on Guerendo with hefty injuries to their running back room, as Christian McCaffrey battled injuries all season while Jordan Mason also carried some of the load previously.