Familial hypercholesterolemia results from gene mutations approximately halving the number of functional LDL receptors in heterozygotes and a greater lack in homozygotes. Reduced receptor-mediated ...

Yet, despite more than 20 years of study, the sweet receptor’s precise architecture remained elusive, even as scientists ...

These medications block an enzyme involved in cholesterol production while enhancing LDL receptor activity, effectively lowering LDL levels by 30-60% depending on the specific statin and dosage.

The participants also had fully functioning LDL receptors and didn't need to be put on a statin. The study concluded not all LDL cholesterol is equal and is not a standalone predictor of heart ...

When the liver makes less LDL cholesterol, the body produces more LDL receptors. LDL receptors are a type of protein on cells that move LDL cholesterol from your blood into your cells. This lowers ...

As a consequence, they lower the hepatic cholesterol pool and promote the expression of LDL receptors in the liver. Bile acid sequestrants are the safest lipid-lowering drugs but have frequent ...

United Kingdom Centre of Membrane Proteins and Receptors, University of Birmingham and Nottingham, The Midlands NG7 2UH, United Kingdom ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In efforts to identify additional therapeutic ...

Figure 2. Potential targets and molecular docking of Rg1 against PD. Venn diagram and drug-targets-disease network of Rg1 targets and PD-related genes. There were 100 Rg1 targets and 9,366 PD-related ...

Objective Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor expressed ... Aspartate transaminase, alanine transaminase (ALT), total cholesterol, LDL cholesterol and HDL ...