When the liver makes less LDL cholesterol, the body produces more LDL receptors. LDL receptors are a type of protein on cells that move LDL cholesterol from your blood into your cells. This lowers ...

Here we report that LD-R-infection promotes fluid-phase endocytosis in the host, selectively accumulating neutral lipids while excluding oxidized-LDL. LD-R enhances the fusion of endocytosed ...

United Kingdom Centre of Membrane Proteins and Receptors, University of Birmingham and Nottingham, The Midlands NG7 2UH, United Kingdom ...

Familial hypercholesterolemia results from gene mutations approximately halving the number of functional LDL receptors in heterozygotes and a greater lack in homozygotes. Reduced receptor-mediated ...

This feature allows it to access liver cells using either asialoglycoprotein receptors or LDL receptors. The new topline data from Heart-2 show that a single infusion of VERVE-102 led to ...

VERVE-102 uses a CRISPR base-editing system to permanently deactivate the PCSK9 gene in liver cells. This increases the number of LDL receptors and lowers LDL-C levels. In April 2024, Verve halted ...

Division of Cardiology, Department of Medicine, University of California, Los Angeles (H.M.S., K.E.J., T.Q.d.A.V., E.J.T.). Division of Cardiology, Department of ...

These receptors are collectively called 'scavenger receptors' and are different from the normal LDL receptor in that they are not regulated by the cholesterol content within the macrophage.

Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Correspondence to: Dr. Siming Guan, Department of Geriatrics, Union ...